Isolation of Novel Disaccharides from Chondroitin Sulfates
نویسندگان
چکیده
منابع مشابه
Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion.
By means of enzymatic digestion with chondroitinase-ABC, a novel unsaturated disaccharide bearing two sulfate residues has been derived from chondroitin sulfate of squid cartilage. Various data, particularly the formation of 2-acetamido-2deoxy-3-0-(P-n-gluco-4-enepyranosyluronic acid)-4-O-sulfoD-galactose and its 6-O-sulfate isomer by hydrolysis with chondro-6-sulfatase and chondro-4-sulfatase,...
متن کاملHyaluronic Acid Chondroitin Chondroitin Sulfates Dermatan Sulfate Keratosulfate Heparin
Polysaccharides (variously called as glycanes or polyholosides or polyosides) are high molecular weight carbohydrates which, on hydrolysis, yield mainly monosaccharides or products related to monosaccharides. They may also be regarded as polymeric anhydrides of simple sugars. D-glucose is the commonest component of polysaccharides. However, D-and L-galactose, D-mannose, D-xylose, L-arabinose as...
متن کاملSolvolytic depolymerization of chondroitin and dermatan sulfates.
It is essential to establish a library of glycosaminoglycan oligosaccharides from the chondroitin and dermatan sulfates to investigate their biological functions and structure-activity relationships (SARs). There are several approaches to obtain oligosaccharides using chemical and enzymatic degradation procedures; however, purification of each resulting oligosaccharide is complicated because of...
متن کاملSynthesis of the Oligosaccharides Related to Branching Sites of Fucosylated Chondroitin Sulfates from Sea Cucumbers
Natural anionic polysaccharides fucosylated chondroitin sulfates (FCS) from sea cucumbers attract great attention nowadays due to their ability to influence various biological processes, such as blood coagulation, thrombosis, angiogenesis, inflammation, bacterial and viral adhesion. To determine pharmacophore fragments in FCS we have started systematic synthesis of oligosaccharides with well-de...
متن کاملFucosylated Chondroitin Sulfates from the Body Wall of the Sea Cucumber Holothuria forskali
Fucosylated chondroitin sulfate (fCS) extracted from the sea cucumber Holothuria forskali is composed of the following repeating trisaccharide unit: → 3)GalNAcβ4,6S(1 → 4) [FucαX(1 → 3)]GlcAβ(1 →, where X stands for different sulfation patterns of fucose (X = 3,4S (46%), 2,4S (39%), and 4S (15%)). As revealed by NMR and molecular dynamics simulations, the fCS repeating unit adopts a conformatio...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1960
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64512-0